Introduction To Biotechnology 3rd Edition By Thieman Palladino – Test Bank

Chapter 11 Medical Biotechnology

1) Which of the following is an example of in vivo gene therapy?
A) Using retroviruses to deliver therapeutic genes directly into a patient
B) Pharmacogenomics
C) Using retroviruses to deliver therapeutic genes into cultured cells
D) Injecting stem cells into a patient
E) None of these choices
Answer: A

2) ________ is the use of genes for treating human genetic disorders.
A) Genetics
B) Genomics
C) Pharmacogenomics
D) Gene therapy
E) Recombinant DNA technology
Answer: D

3) What types of cells fuse together to form hybridomas for making monoclonal antibodies?
A) Bacterial cells and T cells
B) Myeloma cells and B cells
C) Liver cells and antibody-forming cells
D) Monoclonal antibodies and myeloma cells
E) None of these choices
Answer: B

4) Proteins that are produced in a disease tissue and can act as a means of tracking a disease’s progression (such as PSA in prostate cancer) is known as ________.
A) an embryonic marker
B) an STR
C) a microarray
D) a biomarker
E) a tag
Answer: D

5) Which of the following genetic testing techniques would be the best choice for detecting a chromosome translocation?
A) FISH
B) Microarray analysis
C) VNTR analysis
D) ASO test
E) RFLP analysis
Answer: A

6) Which of the following techniques would be the best choice for screening a person’s genetic profile for 1,000 or more genes?
A) FISH
B) Microarray analysis
C) VNTR analysis
D) ASO test
E) RFLP analysis
Answer: B

7) Which of the following is the source of embryonic stem cells?
A) Inner cell mass
B) Spermatozoa
C) Trophoblast
D) Blastocoel
E) Enucleated egg cells
Answer: A

8) The first human genetic disease to be successfully treated by gene therapy was ________.
A) cystic fibrosis
B) sickle cell anemia
C) chronic myelogenous leukemia
D) adenosine deaminase deficiency
E) albinism
Answer: D

9) Which of the following genetic disorders is created by a translocation between chromosome 9 and chromosome 22?
A) Sickle cell anemia
B) Chronic myelogenous leukemia
C) Cystic fibrosis
D) Adenosine deaminase deficiency
E) None of these choices
Answer: B

10) A limitation of retrovirus-mediated gene transfer is that ________.
A) retroviruses cannot be used to make transgenic animals
B) retroviruses only work with Ti vectors
C) retroviruses only integrate DNA at specific sites
D) retroviruses integrate DNA randomly in the genome
E) retroviruses can only be used to make transgenic plants
Answer: D